Cannabidiol (CBD) has shown promise in reducing aggression in mice, a study published in Progress in Neuro-Psychopharmacology and Biological Psychiatry has revealed. The Brazilian researchers conducted an experiment where male mice were isolated for 10 days and their aggressive behavior was observed when intruders were introduced into their cages. The mice that were dosed with CBD displayed fewer and less aggressive attacks compared to the control group.
The researchers believe that CBD works by activating two receptors in the brain, namely the 5-HT1A receptor responsible for serotonin effects and the CB1 receptor responsible for endocannabinoid effects. This mechanism of action is believed to inhibit aggressiveness in the mice.
While previous studies have highlighted CBD’s anti-seizure properties, little research has been done on its effects on aggression. The lead author of the study, Francisco Silveira Guimarães, emphasized the need for further research on CBD’s potential in treating aggressive behavior, especially in patients with psychiatric disorders.
In the study, the mice were divided into groups receiving different doses of CBD, with a control group receiving no CBD. The results showed that lower doses of CBD led to a decrease in aggressive behavior, while higher doses seemed to amplify aggression. This underscores the importance of finding the optimal dose of CBD for reducing aggression without causing unwanted side effects.
While aggressive behavior is currently only considered a qualifying condition for medical marijuana in specific cases, such as self-injurious autism in Delaware, the researchers believe that CBD could have broader applications in treating aggression-related issues in psychiatric patients. However, further research involving human subjects is necessary to validate these claims and ensure safe and effective use of CBD-based medications.
It is important to note that CBD-based medications may have unwanted side effects, such as decreased appetite and diarrhea, particularly in child patients. Therefore, careful consideration and monitoring are essential when using CBD for treating aggression or other conditions.
